The white grape variety originates from Italy. Synonyms are Mantonacu, Mantonacu Viru, Mantonacu Viru della Locride, Mantonica Vera (vera = the "real" Mantonico as opposed to Montonico), Mantonico di Bianco, Mantonico Maclugnese, Mantonico Pizzutella, Mantonico Vero, Mantonicu Pizzutella, Mantonicu Vera and Uva della Scala.

The earliest mentions of this grape variety date back to the 13th century and are mainly known from Sicily. A white Mantonico vine is briefly described by Cupani in his work Hortus Catholicus (1696) on the Palermo region and by Abbot Geremia in his work Vertunno on Mount Etna (1836).
The ancestry (parentage) is unknown. It must not be confused with the varieties Guardavalle (synonym Mantonico) or Montonico Bianco (synonym Mantonico Bianco Italico) due to partly identical or similar synonyms or morphological similarities. The varieties Catarratto Bianco Comune, Brettio Nero, Gaglioppo and Nerello Mascalese are direct descendants of presumably natural crosses.
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