The wine-growing region lies in the east of France between Burgundy and Switzerland. It has a long wine history documented by the Roman wine writer Pliny the Elder (23-79), as evidenced by numerous Roman wine amphorae found here. Wine from this region was already very popular in the Middle Ages and one of its lovers was King Henry IV (1553-1610). It was in the town of Dôle that Louis Pasteur (1822-1895) was born and it was in the town of Arbois that he carried out his pioneering research into oxidation and fermentation. Before the phylloxera disaster, the vineyard area was more than ten times as large, at 20,000 hectares. At that time, more than 40 autochthonous grape varieties were still cultivated.