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The appellation is located in the south of the Entre-deux-Mers area (Bordeaux). There is documentary evidence of viticulture as early as the 13th century. It forms an enclave in the Premières Côtes de Bordeaux appellation. The vineyards cover 400 hectares of vines on clayey limestone soil on the right bank of the Garonne. Opposite on the other bank are the higher quality Barsac and Sauternes areas. The Loupiac appellation is considered for noble sweet white wines from the Sémillon (at least 85%), Sauvignon Blanc and Muscadelle varieties, which are considered the best sweet wines of Entre-Deux-Mers. Well-known wineries include Clos Jean, Château de Ricaud (owned by Alain Thiénot), Château Loupiac-Gaudiet and Château Rondillon.

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