The Italian doctor and naturalist Andrea Bacci (1524-1600) from Sant'Elpidio a Mare in what is now the Marche region studied medicine in Siena and Rome, where he was encouraged by Modestino Cassini, the personal physician of Emperor Maximilian II (1527-1576). Bacci later became the personal physician of Pope Sixtus V (1521-1590). He recommended to him in particular the wines from Liguria from, for example, the Rossese variety, to which he ascribed almost magical powers, saying that "they could even make stones blossom". He taught botany and pharmacy in Rome and wrote numerous pharmacological and toxicological writings. In his main work on natural history "De Naturalis Vinorum Historia" he described Italian wines from many regions. From his native Marche, he reports that the Carthaginian general Hannibal (247-183 B.C.) healed the dull horses of his army during the campaign against Rome by tasting a large quantity of Conero (today DOC Rosso Conero). He also praises the excellent wines of Abruzzo and calls Sardinia the "island of wines".
A wine from the village of Cirella (today's region of Calabria), already mentioned by the Greek historian Strabo (63 BC to 28 AD), he praises with exuberant words. "In the village of Cirella, not far from the river Lao, two types of wine are produced, one light and one red. The first variety, called the wine of Cirella, has taken the name of Chiaretto (rosé wine), because of its brightness and body, and because it could compete with gold for its clarity. Among the other wines, it has the advantage of lasting two or three years, and it deserves to be called the unique example of a more refined wine; it is therefore also considered common at common tables and by the innkeepers, it is extremely pleasant for the palate and the stomach, it quickly slides into the first veins and up to the kidneys, it is very nutritious, produces good and thin blood, brings the remains of the body juices into their natural courses, it is sweat and urine producing, and expels kidney grit. It does not go up to the head, but rather revives all the senses and miraculously drives the spirit of the old and the spiritually sleepy to deep speculations. It exhilarates the heart and soul."