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The "Bodega Colomé" winery is located near the village of Molinos in the Calchaqíes Valley in the Cafayate area of the Salta region. This oldest winery in Argentina was founded in 1831 by the last Spanish governor of Salta, Nicolás Severo de Isasmendi y Echelar. His daughter Ascensión first introduced the Cabernet Sauvignon and Malbec varieties in 1854. The farm remained in the family for 170 years, then passed to the Rodó family for 13 years and was finally sold to the Swiss company Hess Family Estates in 2001. The estate comprises 39,000 hectares of land, most of which is used for sheep and cattle breeding. Part of it is used as a luxurious hotel. Furthermore, there is an important art gallery.

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