The "Bodega Colomé" winery is located near the village of Molinos in the Calchaqíes valley in the Cafayate area of the Salta region. This oldest winery in Argentina was founded in 1831 by the last Spanish governor of Salta, Nicolás Severo de Isasmendi y Echelar. His daughter Ascensión first introduced the Cabernet Sauvignon and Malbec varieties in 1854. The company remained in family ownership for 170 years, then passed into the hands of the Rodó family for 13 years and was finally sold to the Swiss company Hess Family Estates in 2001. The estate covers 39,000 hectares of land, most of which is used for sheep and cattle breeding. A part of it is furnished as a luxurious hotel. There is also an important art gallery.
The vineyards cover 135 hectares and are situated between 2,400 and 3,111 metres above sea level. Aptly named "Altura Maxima" (maximum altitude), the vineyards at over 3,000 metres above sea level are the highest vineyards in the world. The resulting intense sunlight produces particularly hard skinned berries rich in tannin and anthocyanins. The sustainable cultivation of the vineyards is carried out according to the guidelines of Biodynamic viticulture and without the use of chemicals. In some cases, artificial irrigation is necessary. The red wine varieties Malbec(Cot), Cabernet Sauvignon, Merlot, Tannat, Pinot Noir, Tempranillo, Petit Verdot, Syrah and Bonarda, as well as the white wine varieties Chardonnay, Sauvignon Blanc and Torrontés Riojano are cultivated. Three vineyards are partly planted with more than 150 year old root-true vines.