DOC area for a wide range of red, rosé and white wines in the Italian region of Piedmont. The zone comprises around 1,500 hectares of vineyards in the Tortona hill area in just under 50 municipalities on the lower Apennine foothills southeast of the eponymous municipality of Tortona in the province of Alessandria. If the grapes come from classified vineyards, the bottle label may state Vigna followed by the name of the vineyard. There are two subzones, Monleale and Terre di Libarna, whose names may be indicated on the bottle label after Colli Tortonesi for certain types of wine.

The Monleale subzone includes the municipalities of Avolasca, Berzano di Tortona, Brignano-Frascata, Carbonara Scrivia, Carezzano, Casalnoceto, Casasco, Cassano Spinola, Castellania, Castellar Guidobono, Cerreto Grue, Costa Vescovato, Gavazzana, Momperone, Monleale, Montegioco, Montemarzino, Paderna, Pozzol Groppo, Sant'Agata Fossili, Sardigliano, Sarezzano, Spineto Scrivia, Stazzano, Tortona, Viguzzolo, Villalvernia, Villaromagnano, Volpedo and Volpeglino The subzone Terre di Libarna includes the municipalities of Albera Ligure, Arquata Scrivia, Borghetto di Borbera, Cabella Ligure, Cantalupo Ligure, Carrega Ligure, Dernice, Grondona, Mongiardino Ligure, Roccaforte Ligure, Rocchetta Ligure, Stazzano and Vignole Borbera.