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The appellation is located in the Loire wine-growing region at the end of the Loire Valley in the west of France on the coast to the Atlantic Ocean southeast of the city of Nantes. It belongs to the Pays Nantais area. The ancient wine-growing tradition in this region is attested to by a decree of the Roman Emperor Probus (232-282). In the past, red wine varieties were also cultivated here, but the extreme frost of 1709 put an end to this. The Melon de Bourgogne variety, which had already been introduced in the 16th century, developed into a monoculture. It became particularly popular with the Dutch, who were involved in wine-growing and distilled brandy from the wine and marketed it in northern Europe. The name Muscadet, which is commonly used here, eventually gave its name to the area, which was already classified in 1937. The hilly vineyards cover some 13,000 hectares of vines in 54 communes spread across the Loire-Atlantique département. The area is divided into four sub-appellations:

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