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One of the six communes (in addition to Listrac-Médoc, Margaux, Pauillac, Saint-Estèphe and Saint-Julien) within the French Médoc (Haut-Médoc) area which are own appellations and are allowed to carry the communal name on the bottle label. The name (also Moulis-en-Médoc) is derived from the many wind and water mills that used to operate here. The vineyards cover some 600 hectares. The area forms a twelve kilometre long and up to two kilometre wide strip running from southwest to northeast between Margaux and Saint-Julien. The predominant soil consists of deposited gravel on a sandy clay layer. The area lies a little further back from the Gironde and is therefore vulnerable to frost due to the weaker temperature balance caused by the river.

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