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One of the six communes (along with Listrac-Médoc, Margaux, Pauillac, Saint-Estèphe and Saint-Julien) within the French Médoc region (Haut-Médoc) that are appellations in their own right and are allowed to bear the commune name on the bottle label. The name (also Moulis-en-Médoc) derives from the many wind and water mills that used to operate here. The vineyards cover around 600 hectares of vines. The area forms a strip twelve kilometres long and up to two kilometres wide, running from southwest to northeast, between Margaux and Saint-Julien. The predominant soil consists of deposited gravel on a sandy loam layer. The area lies a little further back from the Gironde and is therefore at risk of frost due to the weaker temperature equalisation caused by the river.

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