The winery is located in Malpica de Tajo, 50 kilometres from the city of Toledo in the Spanish region of La Mancha. It is named after the aristocratic previous owner of the same name, whose civil name is Carlos Falcó y Fernández de Córdova. Part of the vineyards has been in the family since 1292. The Marqués began in 1974 in the extremely dry area with the most modern methods of winegrowing and planted the French varieties Cabernet Sauvignon, Chardonnay, Petit Verdot and Syrah, which were not yet permitted at that time. The two famous French oenologists Michel Rolland (*1947) and Émile Peynaud (1912-2004) were involved in the consulting process. In the mid-1970s, the vineyards were pretty much the first in Europe to have artificial irrigation (drip irrigation). The Australian viticulture expert Dr. Richard Smart (*1945) introduced a canopy management system (leaf canopy system, Canopy Management), which he had designed. In 1989 a newly built underground cellar was put into operation.
The total area of the "Finca Casadevacas" estate is 1,400 hectares, but the vineyards account for only 52 hectares. In the past, the winery was granted a special arrangement. The table wines were allowed to bear the designation "Vino de Mesa de Toledo" with year of vintage, although there is no DO area called Toledo. This is now obsolete, because in 2003 the single vineyard Dominio de Valdepusa classified as the highest Spanish wine quality level Vino de Pago. The wines have been produced under this designation ever since. The top product is the red wine cuvée "Eméritus" (Cabernet Sauvignon, Syrah, Petit Verdot), which became a cult wine. Since the wine critic Robert Parker gave the wines his highest rating in 1995, the Marqués has been considered a living legend. For some time now, the Berberana Winery has held shares.
From the end of the 1980s, the activities were extended to other Spanish areas. The beginning was in the area of Rueda (Castilla y León). Since 1994 there is also a winery in Ollauri in the Rioja sub-area Rioja Alta. The vineyards there cover 15 hectares of vines. Rioja wines are produced here in a joint venture with the two wineries Berberana and Lagunilla. Finally, in 2000, 20 hectares of vineyards were acquired in the Duero Valley and wines were produced there in the Ribera del Duero area (Castile and Leon) under the name Bodegas Durius. The property also includes the Marqués de Griñón winery in the Argentinean region of Mendoza. Since 1994, there has been a joint venture with the wine multinational "Arco Bodegas Unidas", which has a significant shareholding. The Marqués de Griñón is still active in a leading position.