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Presumably the ancient advanced civilizations of the Assyrians, Egyptians, Babylonians, Chinese, Persians and Phoenicians were already engaged in the conscious breeding of plants and thus also grape varieties on the basis of wild vines. It was probably known for a very long time that new varieties could be obtained by sowing seeds. Presumably the Persians and later the Arabs in the early Middle Ages already deliberately bred large-berry table grapes, which were spread throughout the Mediterranean region up to Spain (Negrul's Proles orientalis). Modern breeding as a deliberate, manually induced crossing of two parent varieties with the targeted use of paternal pollen probably only began in Christian Europe with the beginning of botanical systematics, for which Carl von Linné (1707-1778) and Charles Darwin (1809-1882) laid the scientific foundations.

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